You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

aroD [2019-07-31 12:14:31]

shikimate dehydrogenase

locus

BSU_25660

6.08

30.49 kDa

protein length

280 aa Sequence Blast

gene length

843 bp Sequence Blast

function

biosynthesis of aromatic amino acids

product

shikimate dehydrogenase

essential

1.1.1.25

synonyms

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

Hide small RNAs Zoom:

categories

[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids]

Gene

Coordinates

2,644,630 2,645,472

The protein

Catalyzed reaction/ biological activity

Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH (according to Swiss-Prot)

Protein family

shikimate dehydrogenase family (single member, according to UniProt)

Structure

[PDB|2HK8] (from ''Aquifex aeolicus'', 42% identity, 61% similarity) [Pubmed|17649975]

Expression and Regulation

Operons

genes

description

[Pubmed|22383849]

view in new tab

Biological materials

Mutant

BKE25660 ([gene|776D79C45DADA631D4A75B0773CFF471A87D9EEC|aroD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE25660 BGSC] and in [SW|Jörg Stülke]'s lab, [Pubmed|28189581], upstream reverse: _UP1_TTTCATACACCTCTCCCCTT, downstream forward: _UP4_ATAGGAAAATTAGGAGGAAC

BKK25660 ([gene|776D79C45DADA631D4A75B0773CFF471A87D9EEC|aroD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK25660 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCATACACCTCTCCCCTT, downstream forward: _UP4_ATAGGAAAATTAGGAGGAAC

References

6811271,24628944,22383849